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Saffron extract

Also known as: Crocus sativus, affron, Satiereal

Extract of the saffron spice, studied in standardized doses for mood.

Common forms: Standardized extract capsules (e.g. affron)

Draft summary, not yet reviewed by a qualified health professional · Last updated 2026-11-03

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This information is for education only and is not medical advice, diagnosis, or treatment. Supplements can interact with medications and health conditions. Check with your doctor or pharmacist before starting anything, especially if you take medication, are pregnant or breastfeeding, or have a health condition. These statements have not been evaluated by the FDA; supplements are not intended to diagnose, treat, cure, or prevent any disease.

What the evidence says

Low mood

BModerate evidence

A GRADE-assessed meta-analysis of 34 randomized trials (moderate certainty) found saffron reduced depressive symptom scores; trials are mostly small and results vary between them.

Dose used in studies
28–30 mg/day standardized extract
Time to effect
4–8 weeks
Studies (2)

Safety

Common side effects

  • Dry mouth
  • Nausea
  • Changes in appetite

Avoid or ask your doctor first if

  • You have bipolar disorder
  • Never take culinary saffron in large amounts (>5 g is toxic)

Pregnancy & breastfeeding

Avoid during pregnancy and breastfeeding.

Medication interactions

  • moderateAntidepressants (SSRI/SNRI): Possible additive serotonergic effects — use only under medical supervision.
  • minorBlood thinners: May affect platelet function.
  • minorBlood pressure medications: May lower blood pressure.

This list covers common medication classes only and is not exhaustive.

Buying tips

Look for third-party testing seals (USP Verified, NSF Certified, or Informed Choice) and match the form and dose used in studies.

Where to buy (affiliate)